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HLDA 9 Barcelona 2010

Most of the molecules used in research and diagnosis by immunologists, hematologists and pathologists derive from the HLDA Workshops. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on leukocytes. CD molecules can act in numerous ways, often acting as receptors or ligands (the molecule that activates a receptor) important to the cell. Click on the CD links below to review the CD details.

CD Page Indices

CD1a-CD35	CD36-CD66a	CD66b-CD97
CD98-CD141	CD142-CD172b	CD172g-CD222
CD223-CD267	CD268-CD309	CD310-CD363

#	N°	Main Expression			CD Search
1	CD1a	Cortical mature thymocytes, dendritic cell subset, Langerhans cells		Expand
		Alternative Name	T6, R4, HTA1
		Definition²	is a human protein encoded by the CD1A gene.This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin.	MW (kDa)	49
		Known Expression	Cortical mature thymocytes, dendritic cell subset, Langerhans cells	Family	IgSF
		Main Functions	restrict T-cell responses to non-peptide lipid and glycolipid antigens	Gene Name	CD1a
		Main Ligands	Microbial lipids and glycolipids	Entrez Gene#	909
		Associated molecules	non-covalent linked to β2 microglobulin	Locus	1q22-23
				Session	T
2	CD1b	Cortical mature thymocytes, dendritic cell subset, Langerhans cells		Expand
		Alternative Name	R1
				MW (kDa)	45
		Known Expression	Cortical mature thymocytes, dendritic cell subset, Langerhans cells	Family	IgSF
		Main Functions		Gene Name	CD1b
		Main Ligands	non-covalent linked to β2 microglobulin	Entrez Gene#	910
		Associated molecules	Microbial lipids and glycolipids	Locus	1q22-23
				Session	T
3	CD1c	Cortical mature thymocytes, dendritic cell subset, Langerhans cells, B cell subset		Expand
		Alternative Name	R7, M241
				MW (kDa)	43
		Known Expression	Expressed on cortical thymocytes (CD4+ CD8+), subset of peripheral blood B cells, a proportion of B cell malignancies, low levels on Langerhans cells, immature myeloid dendritic cells , myeloid leukemias. Intracytoplasmic expression on activated T lymphocytes. Induced on monocytes by treatment with GM-CSF +/- Interleukin-4	Family	IgsF
		Main Functions	restrict T-cell responses to non-peptide lipid and glycolipid antigens	Gene Name	CD1c
		Main Ligands	Microbial lipids and glycolipids	Entrez Gene#	911
		Associated molecules	non-covalent linked to β2 microglobulin	Locus	1q22-23
				Session	T
4	CD1d	Cortical thymocytes, dendritic cell subset, Langerhans cells, intestinal epithelium		Expand
		Alternative Name	R3
				MW (kDa)	38
		Known Expression	CD1d is expressed in NK T cells, Cortical thymocytes, B cells subset, dendritic cell subset, Langerhans cells, intestinal epithelium	Family	IgSF
		Main Functions		Gene Name	CD1d
		Main Ligands	non-covalent linked to β2 microglobulin	Entrez Gene#	912
		Associated molecules	Microbial lipids and glycolipids	Locus	1q22-23
				Session	T
5	CD1e	Cortical thymocytes, dendritic cell subset		Expand
		Alternative Name	R2
				MW (kDa)	36
		Known Expression	Cortical thymocytes, dendritic cell subset	Family	IgSF
		Main Functions		Gene Name	CD1e
		Main Ligands	Microbial lipids and glycolipids	Entrez Gene#	913
		Associated molecules	non-covalent linked to β2 microglobulin	Locus	1q22-23
				Session	T
6	CD2	Thymocytes, T cells, most NK cells, B cells		Expand
		Alternative Name	T11; Tp50; sheep red blood cell (SRBC) receptor; LFA-2
		Definition²	a type I transmembrane protein found on thymocytes, T cells, and some natural killer cells that acts as a ligand for CD58 and CD59 and is involved in signal transduction and cell adhesion; expressed in T-cell acute lymphoblastic leukemia and T-cell lympho	MW (kDa)	50
		Known Expression	Thymo, T, most NK, thymic B (approx. 50%), mature B (controversial)	Family	IgSF
		Main Functions	SRBC receptor,T cell adhesion/activation	Gene Name	CD2
		Main Ligands		Entrez Gene#	914
		Associated molecules	CD58, CD48, Sulfated Carbohydrates (CD59, CD15, )	Locus	1p13
				Session	T
7	CD2R	Activated T cells, NK cells		Expand
		Alternative Name	restricted CD2
				MW (kDa)
		Known Expression		Family
		Main Functions	associated with thymic and peripheral T cell activation	Gene Name
		Main Ligands		Entrez Gene#
		Associated molecules		Locus	1p13
				Session	T
8	CD3δ	T cells		Expand
		Alternative Name	T3, CD3 complex
				MW (kDa)	20
		Known Expression	T cells	Family	T cell receptor complex
		Main Functions	associated with TCR αβ or γδ, role in signal transduction	Gene Name	CD3D
		Main Ligands		Entrez Gene#	915
		Associated molecules		Locus	11q23
				Session	T
9	CD3ε	T cells		Expand
		Alternative Name	-
				MW (kDa)	20
		Known Expression	T cells, Thymo	Family	IgSF
		Main Functions	associated with TCR αβ or γδ, role in signal transduction	Gene Name	CD3E
		Main Ligands		Entrez Gene#	916
		Associated molecules		Locus	11q23
				Session	T
10	CD3γ	T cells		Expand
		Alternative Name	-
				MW (kDa)	25
		Known Expression	T cells	Family	IgSF
		Main Functions	associated with TCR αβ or γδ, role in signal transduction	Gene Name	CD3G
		Main Ligands		Entrez Gene#	917
		Associated molecules		Locus	11q23
				Session	T
11	CD3ζ	see CD247		Expand
		Alternative Name	see CD247
				MW (kDa)	see CD247
		Known Expression	T cells, NK cells, macrophages	Family	see CD247
		Main Functions	see CD247	Gene Name	see CD247
		Main Ligands	see CD247	Entrez Gene#	see CD247
		Associated molecules		Locus	see CD247
				Session	N
12	CD4	Helper/inducer T cells, monocyte subset, thymocyte subset, macrophages		Expand
		Alternative Name	T4
		Definition²	a co-receptor for MHC Class II; also a receptor used by HIV to enter T cells	MW (kDa)	55
		Known Expression	Helper/inducer T cells, monocyte subset, thymocyte subset, macrophages	Family	IgSF
		Main Functions	co-recognition of MHC class II with TCR, primary receptor for HIV retroviruses	Gene Name	CD4
		Main Ligands		Entrez Gene#	920
		Associated molecules	MHC class II, HIV gp120, IL-16, gp17, p56lck (intracellular)	Locus	12pter-p12
				Session	T
13	CD5	Mature T cells, thymocytes, B cell subset		Expand
		Alternative Name	T1, Tp67
		Definition²	a type I transmembrane protein found on T cells, thymocytes, and some B cells that is a ligand for CD72 and is involved in cellular activation or adhesion; expressed in B-cell chronic lymphocytic leukemia and T-cell lymphoma.	MW (kDa)	67 / 58
		Known Expression	Mature T cells, thymocytes, B cell subset	Family	SRCR
		Main Functions	involved in signalling through TCR or BCR	Gene Name	CD5
		Main Ligands	CD72, BCR, TCR	Entrez Gene#	921
		Associated molecules		Locus	11q13
				Session	T
14	CD6	Mature T cells, B cell subset, medullary thymocytes		Expand
		Alternative Name	T12, Tp120
		Definition²	adhesion molecule linking developing thymus-cells to thymus epithelial cells; co-stimulator to mature T cells	MW (kDa)	105 or 130
		Known Expression	Mature T, B sub., immature medullary thymo (low level) and mature thymo (high level), neurons sub.	Family	SRCR
		Main Functions	involved in T cell proliferation, cell adhesion	Gene Name	CD6
		Main Ligands		Entrez Gene#	923
		Associated molecules	CD166	Locus	11q13
				Session	T
15	CD7	Mature T cells, NK cells, immature myeloid cell subset		Expand
		Alternative Name	gp40, Tp41
		Definition²	a type I transmembrane protein found on thymocytes, some T cells, monocytes, natural killer cells, and hemopoietic stem cells; expressed in patients with mycosis fungoides, some patients with T-cell acute lymphoblastic lymphoma, and a few patients with ac	MW (kDa)	40
		Known Expression	Mature T cells, NK cells, immature myeloid cell subset	Family	IgSF
		Main Functions	maybe involved in T and NK cell activation, cell adhesion, cytokine production	Gene Name	CD7
		Main Ligands	Galectin-1	Entrez Gene#	924
		Associated molecules		Locus	17q25.2-q25.3
				Session	T
16	CD8a	Cytotoxic / suppressor T cells, NK cell subset, thymocytes		Expand
		Alternative Name	T8, Leu-2
				MW (kDa)	32-34 / 68
		Known Expression	Cytotoxic / suppressor T cells, NK cell subset, thymocytes	Family	T cell coreceptor
		Main Functions	co-recognition of MHC class I with TCR	Gene Name	CD8A
		Main Ligands		Entrez Gene#	925
		Associated molecules	MHC class I	Locus	2p12
				Session	T
17	CD8b	Cytotoxic / suppressor T cells, NK cell subset, thymocytes		Expand
		Alternative Name	-
				MW (kDa)	30-32 / 68
		Known Expression	Cytotoxic / suppressor T cells, NK cell subset, thymocytes	Family	IgSF
		Main Functions	platelet activation and aggregation, modulates cell adhesion and migration	Gene Name	CD8B1
		Main Ligands	MHC class I	Entrez Gene#	926
		Associated molecules		Locus	2p12
				Session	T
18	CD9	Platelets, activated T cells, eosinophils, basophils, endothelial cells, pre-B cells		Expand
		Alternative Name	p24, MRP-1, MIC3, DRAP-27
		Definition²	a member of the Tetraspanin superfamily expressed in a variety of cells, including: pre B cells, eosinophils, basophils and platelets.	MW (kDa)	24-26
		Known Expression	Platelets, activated T cells, eosinophils, basophils, endothelial cells, pre-B cells	Family	TM4
		Main Functions	modulates cell adhesion and migration, platelet activation	Gene Name	CD9
		Main Ligands		Entrez Gene#	928
		Associated molecules	CD63, CD81, CD82	Locus	2p13
				Session	P
19	CD10	Pre-B cell subset, B cell subset, cortical thymocyte subset, granulocytes, monocyte subset		Expand
		Alternative Name	CALLA, membrane metallo-endopeptidase
		Definition²	a type II transmembrane protein found on pre-B cells, germinal-center B cells, some neutrophils, kidney cells, T-cell precursors, and epithelial cells that acts as a zinc metalloprotease cleaving peptide bonds on the amino side of hydrophobic amino acids;	MW (kDa)	100
		Known Expression	Pre-B cell subset, B cell subset, cortical thymocyte subset, granulocytes, monocyte subset	Family	Zinc metalloprotease
		Main Functions	regulation of B cell growth and proliferation	Gene Name	MME
		Main Ligands	-	Entrez Gene#	4311
		Associated molecules		Locus	3q25.1-q25.2
				Session	B
20	CD11a	Most of lymphoid and myeloid cells		Expand
		Alternative Name	alphaL; LFA-1, gp180/95
		Definition²	Subunit of LFA-1, a membrane glycoprotein that provides cell-cell adhesion by interaction with ICAM-1	MW (kDa)	180/170
		Known Expression	Most of lymphoid and myeloid cells	Family	integrin
		Main Functions	mediates cell-cell adhesion and costimulation,	Gene Name	ITGAL
		Main Ligands	CD18	Entrez Gene#	3683
		Associated molecules	CD54, CD102, CD50, ICAM-4, ICAM-5, CD321, LPS	Locus	16p11.2
				Session	Ad
21	CD11b	Myeloid cells and NK cells		Expand
		Alternative Name	Mac-1, alphaM, Mo1, CR3
		Definition²	Subunit of Mac-1, a complement receptor ("CR3") consisting of CD11b and CD18.	MW (kDa)	170/165
		Known Expression	Myeloid cells and NK cells	Family	integrin
		Main Functions	role in migration of monocytes and neutrophils	Gene Name	ITGAM
		Main Ligands	iC3b, Fibrinogen, CD54, CD102, CD23, LPS, kininogen, haptoglobin, Factor X	Entrez Gene#	3684
		Associated molecules	CD18	Locus	16p11.2
				Session	Ad
22	CD11c	Myeloid cells, NK cells macrophages, activated T cells		Expand
		Alternative Name	p150,95, alphaX integrin chain, CR4, axb2
		Definition²	a type I transmembrane protein found on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-ce	MW (kDa)	150/145
		Known Expression	mono, macro, NK, granulo, T and B cells (act.), DC (myeloid)	Family	integrin
		Main Functions	role in cytotoxic T cell killing	Gene Name	ITGAX
		Main Ligands	CD18	Entrez Gene#	3687
		Associated molecules	iC3b, fibrinogen, CD54, CD23, LPS	Locus	16p11.2
				Session	Ad
23	CD11d	Leucocytes		Expand
		Alternative Name	integrin aD subunit
				MW (kDa)
		Known Expression	Leuko, Macro	Family	integrin
		Main Functions	-	Gene Name
		Main Ligands	CD50	Entrez Gene#
		Associated molecules	CD18	Locus
				Session	Ad
24	CDw12	Monocytes, granulocytes, platelets and NK cells		Expand
		Alternative Name	p90-120
		Definition²	unknown	MW (kDa)	120/150-160
		Known Expression	Monocytes, granulocytes, platelets and NK cells	Family	-
		Main Functions	-	Gene Name	CDw12
		Main Ligands		Entrez Gene#	23444
		Associated molecules	-	Locus
				Session	M
25	CD13	Monocytes, neutrophils		Expand
		Alternative Name	APN, (EC 3.4.11.2), gp150
		Definition²	a zinc metalloproteinase, also known as aminopeptidase N, which is found naturally on myelomonocytic cells from early differentiation through maturity; usually present on acute myeloid leukemia blasts and rarely found in some forms of lymphoma and lymphoc	MW (kDa)	150
		Known Expression	Monocytes, neutrophils	Family	-
		Main Functions	inactivates biologically active peptides, acts as a receptor for coronaviruses	Gene Name	ANPEP
		Main Ligands	Coronaviruses, cytomegaloviruses	Entrez Gene#	290
		Associated molecules		Locus	15q25-q26
				Session	M
26	CD14	Monocytes, macrophages, Langerhans cells		Expand
		Alternative Name	LPS receptor
		Definition²	a membrane protein found on macrophages which binds to bacterial lipopolysaccharide.	MW (kDa)	55/53
		Known Expression	Monocytes, macrophages, Langerhans cells	Family	LRG
		Main Functions	receptor for LPS and LBP	Gene Name	CD14
		Main Ligands		Entrez Gene#	929
		Associated molecules	LBP, LPS	Locus	5q31.1
				Session	M
27	CD15	Neutrophils, eosinophils, monocytes, Reed Sternberg cells		Expand
		Alternative Name	Lewis X (Lex), 3-fucosyl-N-acetyl-lactosamine ( 3-FAL)
		Definition²	a carbohydrate adhesion molecule (not a protein) that mediates phagocytosis and chemotaxis, found on neutrophils; expressed in patients with Hodgkin disease, some B-cell chronic lymphocytic leukemias, acute lymphoblastic leukemias, and most acute nonlymph	MW (kDa)
		Known Expression	Neutrophils, eosinophils, monocytes, Reed Sternberg cells	Family	carbohydrate 2
		Main Functions	involved in neutrophil adhesion and phagocytosis	Gene Name
		Main Ligands	selectins	Entrez Gene#
		Associated molecules		Locus
				Session	Ad
28	CD15s	Neutrophils, basophils, monocytes		Expand
		Alternative Name	sialyl Lewis X
				MW (kDa)
		Known Expression	Neutro, baso, mono, Lymph Node, Endothelium, granulocytes, eosino, activated T, activated B, NK	Family	sialylated carbohydrate 2
		Main Functions	ligand for CD62E, CD62P and CD62L	Gene Name
		Main Ligands		Entrez Gene#
		Associated molecules	CD62E, CD62P	Locus
				Session	Ad
29	CD15u	Granulocytes, Monocytes,B cell subset, T cell subset, NK cells, Endothelial cells		Expand
		Alternative Name	sulfated Lewis X
				MW (kDa)
		Known Expression	Granulocytes, Monocytes,B cell subset, T cell subset, NK cells, Endothelial cells	Family
		Main Functions		Gene Name
		Main Ligands	CD62L	Entrez Gene#
		Associated molecules		Locus
				Session	Ca
30	CD16a	NK cells, macrophages, mast cells, monocytes		Expand
		Alternative Name	Fc gamma RIIIa
				MW (kDa)	50-60
		Known Expression	NK cells, macrophages, mast cells, monocytes	Family	IgSF
		Main Functions	mediates signal transduction on NK cells	Gene Name	FCGR3A
		Main Ligands		Entrez Gene#	2214
		Associated molecules	CD33, FceRIg chain	Locus	1q23
				Session	N
31	CD16b	Granulocytes neutrophil only		Expand
		Alternative Name	Fc gamma RIIIb
				MW (kDa)	50-60
		Known Expression	Granulocytes neutrophil only	Family	IgSF
		Main Functions		Gene Name	FCGR3B
		Main Ligands	-	Entrez Gene#	2215
		Associated molecules		Locus	1q23
				Session	N
32	CD17	Neutrophils, basophils, monocytes, platelets, B cell subset		Expand
		Alternative Name	LacCer
				MW (kDa)
		Known Expression	Neutrophils, basophils, monocytes, platelets, B cell subset	Family	LacCer
		Main Functions	possible role in phagocytosis and signal transduction	Gene Name
		Main Ligands		Entrez Gene#
		Associated molecules	GM3 gangliosides	Locus
				Session	M
33	CD18	Leucocytes		Expand
		Alternative Name	beta2 integrin chain
		Definition²	adhesion and signaling in the hematopoietic system.	MW (kDa)	95/>120
		Known Expression	Leucocytes	Family	integrin
		Main Functions	heterodimer with CD11a,b, c or D (a chains), interaction with a-actinin and filamin	Gene Name	ITGB2
		Main Ligands	CD11a, CD11b, CD11c	Entrez Gene#	3689
		Associated molecules		Locus	21q22.3
				Session	Ad
34	CD19	Precursor B cells and B cells, follicular dendritic cells		Expand
		Alternative Name	B4 , Bgp95
		Definition²	B-lymphocyte surface antigen B4	MW (kDa)
		Known Expression	Precursor B cells and B cells, follicular dendritic cells	Family	IgSF
		Main Functions	signal transduction regulating B cell responsiveness	Gene Name	CD19
		Main Ligands	CD21, CD81, lyn, lck, fyn, Vav and phosphoinositide 3-kinase following tyrosine phosphorylation	Entrez Gene#	930
		Associated molecules	CD77	Locus	16p11.2
				Session	B
35	CD20	Precursor B cell subset, B cells		Expand
		Alternative Name	B1, Bp35
		Definition²	a type III transmembrane protein found on B cells that forms a calcium channel in the cell membrane allowing for the influx of calcium required for cell activation; expressed in B-cell lymphomas, hairy cell leukemia, and B-cell chronic lymphocytic leukemi	MW (kDa)	33, 35, 37
		Known Expression	Precursor B cell subset, B cells	Family	CD20
		Main Functions	B cell Ca++ channel subunit, regulation of cell cycle progression	Gene Name	MS4A1
		Main Ligands		Entrez Gene#	931
		Associated molecules	CD53, CD81, CD82, lyn, lck, fyn,	Locus	11q12-q13.1
				Session	B
36	CD21	Mature B cells, follicular dendritic cells, thymocyte subset		Expand
		Alternative Name	CR2, EBV-R, C3d-receptor
		Definition²	a type I transmembrane protein found on B cells, follicular dendritic cells, pharyngeal and cervical epithelial cells, some thymocytes, and some T cells that plays a role in signal transduction; expressed in hairy cell leukemia, B-cell lymphoma, and some T-cell acute lymphocytic leukemias. CR2, a type I transmembrane protein found in the cytoplasm of pre-B cells and on the surface of mature B cells that facilitates signal transduction; expressed in patients with hairy cell leukemias and in some with B-cell lymphomas. Receptor for complement (C3d) and Epstein-Barr virus (EBV).	MW (kDa)	(130), 145
		Known Expression	B cells (mature), DC (follicular), thymo (sub.)	Family	RCA
		Main Functions	involved in B cell activation/proliferation, part of signal transduction complex	Gene Name	CR2
		Main Ligands	CD19, CD81, Leu13	Entrez Gene#	1380
		Associated molecules	C3d, C3dg, iC3b, EBV, CD23, CD35	Locus	1q32
				Session	B
37	CD22	Precursor and mature B cells		Expand
		Alternative Name	BL-CAM, Siglec2
		Definition²	a sugar binding transmembrane protein that specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. It is a member of the immunoglobulin superfamily and the SIGLEC family. CD22 functions as an inhibitory receptor for B	MW (kDa)	140, (130)
		Known Expression	Precursor and mature B cells	Family	IgSF
		Main Functions	mediates adhesion: a form to monocytes & erythrocytes, b form to T cells and B cells	Gene Name	CD22
		Main Ligands	sialytated glycoproteins	Entrez Gene#	933
		Associated molecules	CD45, IgM, haptoglobin	Locus	19q13.1
				Session	B
38	CD23	B cells, monocytes, follicular dendritic cells		Expand
		Alternative Name	Fc epsilonRII, Blast-2, low affinity IgE receptor, IGEBF, Leu-20, B6
		Definition²	a type II transmembrane protein found on mature B cells, monocytes, activated macrophages, eosinophils, platelets, and dendritic cells that enhances capture and processing of antigen complexed with IgE.	MW (kDa)	45, (37, 29, 25, 16)
		Known Expression	B cells, monocytes, follicular dendritic cells	Family	IgSF
		Main Functions	regulation of IgE synthesis, mediates cytotoxicity by macrophages & eosinophils	Gene Name	FCER2
		Main Ligands		Entrez Gene#	2208
		Associated molecules	MHC class II, IgE, CD21	Locus	19p13.3
				Session	B
39	CD24	B cells, granulocytes		Expand
		Alternative Name	BA-1, HSA
		Definition²	a glycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and in many B cells. The encoded protein is anchored via a glycosyl phosphatidyli	MW (kDa)	35-70
		Known Expression	B cells, granulocytes	Family	CD52/CD24/HSA
		Main Functions	activation of mature B cells	Gene Name	CD24
		Main Ligands	CD62P	Entrez Gene#	934
		Associated molecules		Locus	6g21
				Session	B
40	CD25	Activated T and B cells, stimulated monocytes/macrophages		Expand
		Alternative Name	IL-2Ra, Tac antigen
		Definition²	a type I transmembrane protein present on activated T cells, activated B cells, some thymocytes, myeloid precursors, and oligodendrocytes that associates with CD122 to form a heterodimer that can act as a high-affinity receptor for IL-2; expressed in most	MW (kDa)	55
		Known Expression	Activated T and B cells, stimulated monocytes/macrophages	Family	CK-R
		Main Functions	-	Gene Name	IL2RA
		Main Ligands	CD122, CD132	Entrez Gene#	3559
		Associated molecules	IL-2,	Locus	10p15-p14
				Session	Ck
41	CD26	Mature thymocytes, activated T cells, B cells, macrophages, NK cells		Expand
		Alternative Name	DPPIV ectoenzyme, ADA-binding protein
		Definition²	Membrane-bound protease. T-cell costimulatory molecule. Cell adhesion molecule	MW (kDa)	120-110/110
		Known Expression	Mature thymocytes, activated T cells, B cells, macrophages, NK cells	Family	serine-type exopeptidase
		Main Functions	involved in T cell activation	Gene Name	DPPA
		Main Ligands	Adenosine deaminase, collagen, FAP, Tat of HIV	Entrez Gene#	1803
		Associated molecules	CD45	Locus	2q24.3
				Session	X
42	CD27	Mature T cells, B cell subset, NK cells		Expand
		Alternative Name	T14, S152
		Definition²	TNF-receptor. Present on the surface of resting memory B cells.	MW (kDa)	55/110-120
		Known Expression	Mature T, B sub., NK	Family	TNFR
		Main Functions	involved in T- and B- cell activation / proliferation	Gene Name	TNFRSF7
		Main Ligands	SIVA, TRAF5, TRAF2	Entrez Gene#	939
		Associated molecules	CD70	Locus	12p13
				Session	T
43	CD28	Mature thymocytes subset, T cells, plasma cells		Expand
		Alternative Name	Tp44
		Definition²	present on all T-cells, and when matched with the appropriate ligand, labeled B7 which can be either CD80 or CD86, it has costimulatory effect on the T-cell. It is also expressed on Eosinophil granulocytes, especially after tissue infiltration. There its	MW (kDa)	44/90
		Known Expression	Mature thymocytes subset, T cells, plasma cells	Family	IgSF
		Main Functions	T cell co-stimulatory signal	Gene Name	CD28
		Main Ligands	CD80, CD86	Entrez Gene#	940
		Associated molecules		Locus	2q33
				Session	T
44	CD29	Broad		Expand
		Alternative Name	platelet GPIIa, VLA-beta chain, Integrin beta1 chain
		Definition²	AKA integrin beta-1 - a cell adhesion molecule.	MW (kDa)	130/115
		Known Expression	Broad	Family	integrin
		Main Functions	heterodimer with CD49a-f (a chains), adhesion to cell surface ligands and extracellular matrices	Gene Name	ITGB1
		Main Ligands	CD49a-f, CD51	Entrez Gene#	3688
		Associated molecules	VCAM-1, MadCAM-1, fibronectin, laminin...	Locus	10p11.2
				Session	Ad
45	CD30	Activated T & B cells, activated NK cells, monocytes, Reed Sternberg cells		Expand
		Alternative Name	Ki-1 antigen Ber-H2 antigen
		Definition²	a type I transmembrane protein present on activated T and B cells that may play a role in cell activation and/or differentiation; expressed in Hodgkin disease, some T-cell lymphomas, and anaplastic large cell lymphomas.	MW (kDa)	105/120
		Known Expression	Activated T & B cells, activated NK cells, monocytes and endothelial cells - marker on TH2 cells, TH0 and TH1 cells as well as on CD8+ T-cells (at lower levels). - A variant form of CD30 (CD30v) having only the cytoplasmic domain is expressed in alveolar macrophages. - Soluble form of Mr 85,000 produced by metalloproteinase	Family	TNFR/NGFR
		Main Functions	involved in T cell activation	Gene Name	TNFRSF8
		Main Ligands	CD153 (CD30 L)	Entrez Gene#	943
		Associated molecules	TRAF1, TRAF2, TRAF3, TRAF5 associated with cytoplasmic tail of CD30	Locus	1p36
				Session	X
46	CD31	Platelets, endothelial cells, monocytes, NK cells, neutrophils, T cell subset		Expand
		Alternative Name	PECAM-1, platelet GPIIa’, endocam
		Definition²	PECAM-1, a cell adhesion molecule on platelets and endothelial cells	MW (kDa)	130-140
		Known Expression	Platelets, endothelial cells, monocytes, NK cells, neutrophils, T cell subset	Family	IgSF
		Main Functions	mediates adhesion between cells bearing CD31	Gene Name	PECAM1
		Main Ligands		Entrez Gene#	5175
		Associated molecules	CD31, CD38	Locus	17q23
				Session	Ad
47	CD32	Broad except NK cells		Expand
		Alternative Name	Fc gamma RII
		Definition²	FcγRII, a receptor for the Fc (constant) region of immunoglobulin G (IgG)	MW (kDa)	40
		Known Expression	Broad except NK cells	Family	Fc receptor
		Main Functions	regulatory role in B cells	Gene Name	FCGR2A
		Main Ligands	IgG aggregates or complexes with antigen.	Entrez Gene#	2212
		Associated molecules		Locus	1q23
				Session	M
48	CD33	Pan myeloid, majority of monocytic cells		Expand
		Alternative Name	My9, gp67, p67, Siglec3
		Definition²	a marker of unknown function found on immature myeloid cells, including acute myeloid leukemia blasts and mature monocytes	MW (kDa)	67/150
		Known Expression	Myeloid progenitors (CFU-GEMM, CFU-GM, CFU-G, BFU-E). Mono/Macro. Granulo precursors (promyelocytes, myelocytes etc, decreasing expression with maturation and differentiation). Mature granulo (low level expression). No known expression outside of the hematopoietic system. CD33 is an important marker for distinguishing myeloid from lymphoid leukemias.	Family	IgSF
		Main Functions	Negative regulatory role in myeloid hematopoiesis.	Gene Name	CD33
		Main Ligands		Entrez Gene#	945
		Associated molecules	α2,3- and α2,6-linked sialic acid bearing glycans.	Locus	19q13.3
				Session	M
49	CD34	Hematopoietic precursor cells, endothelial cells		Expand
		Alternative Name	gp105-120
		Definition²	stem cell marker, adhesion, found on hematopoietic precursors (found in high concentrations in umbilical cord blood), capillary endothelium, and embryonic fibroblasts	MW (kDa)	40
		Known Expression	Hematopoietic precursor cells, endothelial cells	Family	sialomucin
		Main Functions	3 epitope classes already known: I,II and III, role in cell-cell adhesion homing of lymphocytes	Gene Name	CD34
		Main Ligands	CD62L, CD62E	Entrez Gene#	947
		Associated molecules		Locus	1q32
				Session	M
50	CD35	Neutrophils, eosinophils, monocytes, follicular dendritic cells, B cells, erythrocytes, T cell subset		Expand
		Alternative Name	CR1, C3b/C4b receptor, Immune Adherence Receptor
		Definition²	Complement receptor 1 (C3b/C4b receptor)	MW (kDa)	190-280/160-250
		Known Expression	neutro, eosino, mono, DC (follicular), B cells, erythro, T cells (sub.)	Family	RCA
		Main Functions	mediates adherence of C4b/C3d-coated particles for phagocytosis	Gene Name	CR1
		Main Ligands		Entrez Gene#	1378
		Associated molecules	C3b, C4b, iC3b, C3dg, iC3, iC4	Locus	1q32
				Session	M

Session Keys & Color Codes

Ad	Adhesion	B	B cells	Ca	Carbohydrates/lectins
Ck	Cytokines/chemokines	D	Dendritic cells	En	Endothelial cells
Er	Erythroid cells	M	Myeloid cells	P	Platelets
S	Stem cells	T	T cells	X	Blind panel

References

HLDA 1: Leucocyte Typing - Bernard, A., et al. Eds., Springer-Verlag (1984)
HLDA 2: Leucocyte Typing II - Reinherz, E.L., et al. Eds., Springer-Verlag (1986)
HLDA 3: Leucocyte Typing III - McMichael, A.J., et al. Eds., Oxford University Press (1987)
HLDA 4: Leucocyte Typing IV - KnappW., et al. Eds., Oxford University Press (1989)
HLDA 5: Leucocyte Typing V - Schlossman, S.F., et al. Eds., Oxford University Press (1995)
HLDA 6: Leucocyte Typing VI - Kishimoto, T., et al. Eds., Garland Publishing, Inc. (1997)
HLDA 7: Leucocyte Typing VII - Mason, D., et al. Eds., Oxford University Press (2002)
Leukocyte and Stromal Cell Molecules The CD Markers - H. Zola, B. Swart, I. Nicholson, E. Voss. Wiley (2007)
Bennett JS. Structure and function of the platelet integrin alphaIIbbeta3. J Clin Invest 2005; 115:3363-9.

CD Definitions: Wikipedia®

The National Center for Biotechnology Information
The HCDM (Human Cell Differentiation Molecules)
The HLDA9 Workshop

Zola H, Swart B, Nicholson I, Aasted B, Bensussan A, Boumsell L, Buckley C, Clark G, Drbal K, Engel P, Hart D, Horejsí V, Isacke C, Macardle P, Malavasi F, Mason D, Olive D, Saalmueller A, Schlossman SF, Schwartz-Albiez R, Simmons P, Tedder TF, Uguccioni M, Warren H. CD molecules 2005: human cell differentiation molecules Blood. 2005 Nov 1;106(9):3123-6. Epub 2005 Jul 14. pubMedID:16020511

Zola H, Swart B, Banham A, Barry S, Beare A, Bensussan A, Boumsell L, Buckley C, Bühring HJ, Clark G, Engel P, Fox D, Jin BQ, Macardle PJ, Malavasi F, Mason D, Stockinger H, Yang X. CD molecules 2006--human cell differentiation molecules.J Immunol Methods. 2007 Jan 30;319(1-2):1-5. Epub 2006 Dec 4. pubMedID: 17174972

7th HLDA Workshop poster

CD1a-CD35

CD36-CD66a

CD66b-CD97

Page 1

From CD1a to CD 35

Page 2

From CD36 to CD66a

Page 3

From CD66b to CD97

CD98-CD141

CD142-CD172b

CD172g-CD222

Page 4

From CD98 to CD141

Page 5

From CD142 to CD172b

Page 6

From CD172g to CD222

CD223-CD267

CD268-CD309

CD310-CD363

Page 7

From CD223 to CD267

Page 8

From CD268 to CD309

Page 9

From CD310 to CD363

CDs defined by the different HLDA Workshop (1982-2010)
Human leukocyte differentiation antigens (HLDA) Workshops have proven to be instrumental in the identification and characterization of a large number of molecules that populate the surface of hematopoietic cells.

#	HLDA	City	Year	CDs defined by the different HLDA Workshop
1	Workshop I	Paris	1982	CD10
2	Workshop II	Boston	1984	CD19, CD20, CD21, CD22, CD23, CD24
				Preferentially expressed on B-cells
3	Workshop III	Oxford	1986	CD37, CD38, CD39, CD40
4	Workshop IV	Vienna	1989	CD72, CD73, CD74, CD75, CD76, CD77, CDw78
5	Workshop V	Boston	1993	CD79a, CD79b, CD80, CD82, CD83, CD84, CD85, CD86
				Components of the B-cell receptor: CD79a (Igα), CD79b (Igß), CD179a (V preB), CD179b (Lambda 5)
6	Workshop VI	Kobe	1996	CD138, CD139
7	Workshop VII	Harrogate	2000	CD179a, CD179b, CD180
				Components of the B-cell receptor: CD79a (Igα), CD79b (Igß), CD179a (V preB), CD179b (Lambda 5)
8	Workshop VIII	Adelaide	2004	CD267, CD269, CD307e, CD252, CD254, CD268, CD275, CD315, CD316, CD317
				Preferentially expressed on B-cells
9	Workshop IX	Barcelona	2010	CD307a, CD307b, CD307d, CD307c, CD351, CD352, CD353, CD354, CD355, CD356, CD357, CD358, CD359, CD360, CD361, CD362, CD363
				Preferentially expressed on B-cells
				HLDA 9 - Closing Presentation by Pablo Engel
				Department of Cellular Biology - Immunology and Neurosciences; University of Barcelona - Medical School