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Mature B-Cell Neoplasms and Mature T-Cell and NK-Cell Neoplasms Slide Rulers

Immune Monitoring  On-line Lymphoid Slide Ruler
Click on the arrows or red title header to flip between the Mature B-Cell Neoplasms and Mature T-Cell and the NK-Cell Neoplasms slide rulers. Place your mouse cursor above the disease abbreviations to slide the ruler. Drag the cursor over the respective CD's or colored boxes to reveal the desired results.
We have also made available a portable version of this slide ruler for your lab or office. Click here to request this quick reference tool designed by Michel Herbert - Marketing Manager - Clinical Reagents for Flow Cytometry, Beckman Coulter Inc. Marseille, France


 

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Abbreviations Notes
Aggr. NK-L = Aggressive NK-Cell Leukemia
AITL = Angioimmunoblastic T-Cell Lymphoma
ATLL = Adult T-Cell Leukemia / Lymphoma
B-CLL/SLL = B-Cell Chronic Lymphocytic Leukemia / Small Lymphocytic Lymphoma
BM = Bone Marrow
B-PLL = B-Cell Prolymphocytic Leukemia
Burkitt = Burkitt Lymphoma
CLPD-NK = Chronic Lymphoproliferative Disorders of NK Cells
DLBCL (NOS) = Diffuse Large B-Cell Lymphoma, not otherwise specified
EATL = Enteropathy-Associated T-Cell Lymphoma
FL = Follicular Lymphoma
HCD = Heavy Chain Diseases
HCL = Hairy Cell Leukemia
HSTL = Hepatosplenic T-Cell Lymphoma
KIR = Killer-cell Immunoglobulin-like Receptor
LPL = Lymphoplasmacytic Lymphoma
MALT-L = Mucosa-Associated Lymphoid Tissue Lymphoma
MCL = Mantle Cell Lymphoma
MF = Mycosis Fungoides
NMZL = Nodal Marginal Zone Lymphoma
PCM = Plasma Cell Myeloma
PTCL (NOS) = Peripheral T-Cell Lymphoma, not otherwise specified
Sézary S = Sézary Syndrome
SMZL = Splenic Marginal Zone Lymphoma
SPTCL = Subcutaneous Panniculitis-Like T-Cell Lymphoma
T-LGL = T-Cell Large Granular Lymphocyte Leukemia
T-PLL = T-Cell Prolymphocytic Leukemia
Type II EATL = Type II Enteropathy-Associated T-Cell Lymphoma
 
(1) Waldenström macroglobulinema (9761/3) is found in a significant subset of patients with LPL with BM involvement and an IgM monoclonal gammopathy of any concentration.
(2) Typically IgM+, and less often IgA+ or IgG+.
(3) IgD is positive in a minority of the cases.
(4) IgM+/-, IgD, IgG or rarely IgA.
(5) More frequently with Lambda than Kappa restriction.
 (6) The membrane expression of CD3 may be weak.
(7) 25% of patients coexpress CD8 with CD4, a feature
almost unique to T-PLL; 15% are CD4-neg, CD8-pos.
(8) Expression of CD94 and KIR families of receptors can be detected in 50% or more of cases.
(9) Uncommon variants include CD4 TCRαβ-pos cases and TCRγδ-pos cases; approximately 60% of the latter express CD8, the remainder are CD4/CD8 double negative.
(10) Abnormal uniform expression of CD8 can be seen.
(11) KIR-pos cases preferentially express activating receptor isoforms.
(12) If TCRαβ-pos, expect different immunophenotype for the rest of the markers.
(13) A CD4-pos/CD8-neg phenotype predominates in nodal cases. CD4/CD8 double positivity or double negativity is at times seen.
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For Research Use Only. Not for use in diagnostic procedures
Source: WHO Classification of Tumours of Hæmatopoietic and Lymphoid Tissues, 4th Edition, Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J and Vardiman JW (Eds.): IARC Press, Lyon (2008).
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